This presentation will introduce the art of administering a propofol-remifentanil admixture by microbolus and continuous infusion to achieve a dose-dependent choice of moderate sedation, deep sedation or general anesthesia. Doses, caveats, limitations, complications and monitoring during this exciting technique will be reviewed. The premise is obvious: when used properly, this technique markedly improves anesthetic control for both short and long cases, thereby increasing safety.